Gamma‐aminobutyric acid (GABA): a para‐ and/or autocrine hormone in the pituitary
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منابع مشابه
Gamma-aminobutyric acid (GABA): a para- and/or autocrine hormone in the pituitary.
ARTUR MAYERHOFER,* BARBARA HÖHNE-ZELL,* KATIA GAMEL-DIDELON,* HEIKE JUNG, PETER REDECKER, DIETRICH GRUBE, HENRYK F. URBANSKI, BRUNO GASNIER, JEAN-MARC FRITSCHY, AND MANFRED GRATZL* *Anatomisches Institut der Universität München, Germany; Zentrum Kinderheilkunde und Humangenetik der Medizinischen Hochschule and Abteilung Anatomie I der Medizinischen Hochschule Hannover, Germany; Division of Neur...
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There is increasing evidence suggesting that the neurotransmitter gamma-aminobutyric acid (GABA) is a local factor involved in the regulation of endocrine organs. Examples of such functions are documented in the pancreas, but recent results suggest that GABA may act in a similar way in the pituitary, in which GABA receptors are expressed and pituitary growth hormone (GH) cells provide a source ...
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The amino acid content in human hypophyseal growth hormone has been determined by chromatography on resin columns. On the basis of 29,000 for the molecular weight, the empirical formula of the hormone was obtained: lys(13)his(5)arg(14)asp(27) thr(14)ser(23)glu(34)pro(12)gly(13)ala(12)-(1/2 cys)(6)val(12)met(4)-ileu(10)leu(31)tyr(10)phe(15)try(1)(NH(3))(32).
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OBJECTIVE Paracrine signaling via gamma-aminobutyric acid (GABA) and GABA(A) receptors (GABA(A)Rs) has been documented in rodent islets. Here we have studied the importance of GABAergic signaling in human pancreatic islets. RESEARCH DESIGN AND METHODS Expression of GABA(A)Rs in islet cells was investigated by quantitative PCR, immunohistochemistry, and patch-clamp experiments. Hormone release...
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Cellular senescence is a stable proliferative arrest state. Pituitary adenomas are frequent and mostly benign, but the mechanism for this remains unknown. IL-6 is involved in pituitary tumor progression and is produced by the tumoral cells. In a cell autonomous fashion, IL-6 participates in oncogene-induced senescence in transduced human melanocytes. Here we prove that autocrine IL-6 participat...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2001
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fsb2fj000546fje